Thursday, February 28, 2019

Top 10 Bioinformatics Companies in India

Here is the alphabetical  list of top 10 Bioinformatics companies in India

1. Accelrys Software Solution Pvt Ltd.
12th Floor, Discover, ITPL, White Field, Bangalore-65.
www.accelrys.com

2. Bio Base Databases India Pvt Ltd.
Crescent Towers, 4th Floor, No : 32/1, Crescent Road, Bnagalore – 560 001
www.biobase-international.com

3. BioInformatics Institute Of India – Noida
C-56 A/28, Sector -62, Noida – 201 301
www.bii.in

4. BioTrail Bio IT Solutions
Ward No - 19, Lakshmangarh, Rajasthan, India-332311
www.biotrail.in

5. CLC bio India Pvt Ltd
#Plot No. 51, H.No. 8-3-214/51, Srinivasa Nagar (West) Ameerpet Hyderabad – 500 038
www.clcbio.com/india

6. Genotypic Technology
211, 6th Cross, 80ft Road, RMV II Stage, Bangalore 560094
www.genotypic.co.in

7. Jubilant Biosys Ltd
#96, Industrial Subrub, 2nd Stage, Yeshwanthpur, Bangalore- 560022
Jubilant Organosys Ltd.
1A, Sector 16A, Noida – 201 301 (India)
www.jubl.com

8. Mascon Global Limited
B – 8/ 10, Vasant Vihar, New Delhi 110057, India
www.mgl.com

9. Ocimum Biosolutions (India) Ltd
6th Floor, Reliance Classic, Road No.1 Banjara Hills, Hyderabad 500 034, India.
www.ocimumbio.com

10. Strand Life Sciences Pvt. Ltd.
#237, Sir C. V. Raman Avenue, Raj Mahal Vilas, Bangalore 560 080 INDIA
www.strandls.com

Sunday, July 1, 2018

Pakistani media on education standard between muslims and non muslims पाकिस्तानी मीडिया द्वारा मुस्लिम और नॉन मुस्लिम के बीच शिक्षा की तुलना

Pakistani media on education standard between muslims and non muslims पाकिस्तानी मीडिया द्वारा मुस्लिम और नॉन मुस्लिम के बीच शिक्षा की तुलना
Please watch the video
https://www.youtube.com/watch?v=nLi4pC1gUzs

Friday, May 18, 2018

Nice and simple app to remind you your baby vaccination dates

This simple android app lets you store your baby date of birth and tells their immunization date deadlines. Details according to National Immunization Program India are stored in the app.

https://play.google.com/store/apps/details?id=com.androidwarez.rkt.droidimmunizationreminder

Saturday, November 12, 2016

How to store, manage and cite bibliographic references using zotero

This video shows how you can use Zotero to manage, cite references in your research articles.
After installing Zotero and it's plugin for Microsoft Word in windows system, you need to add all the research articles to Zotero using their PMID, DOI, ISBN ids.
Then you can easily cite these references to any document through  Zotero plugin in Microsoft Word.



Thursday, June 20, 2013

How to calculate Dihedral Angle using Cartesian Coordinates or using RasMol

Dihedral angle is an angle between two planes.

Protein backbone dihedral angles are called φ (phi), involving the backbone atoms COn-1 - Nn - Cαn - COn , ψ (psi) involving the backbone atoms Nn - Cαn - COn - Nn+1) and ω (omega) involving the backbone atoms Cαn - COn - Nn+1 - Cαn+1). Thus, φ controls the COn-1 - COn distance, ψ controls the Nn - Nn+1 distance and ω controls the Cαn - Cαn+1 distance. Where n is the current atom for which you want to calculate the dihedral angles. Dihedral angle varies between -180 to +180. It is positive if rotation between atoms is clockwise and negative if rotation is anticlockwise.

To calculate phi for a residue "n" we need CO atom of n-1 residue thus we can not calculate phi for first residue of protein backbone similarly to calculate psi of residue "n" we need N atom of residue n+1 thus psi for last atom in protein backbone can not be calculated.


Calculate Dihedral Angle using Cartesian Coordinates


Atom arrangement is shown in figure 1 and 2. Figure 2 is newman projection of atom A, B, C, D, angle between A and D if we see arrangement through B-C axis is dihedral angle Ɵ. x,y,z are cartesian coordinates of atoms.


Thus using cartesian coordinates of these atoms these angles can be calculated by following method -

Using atom A, B, C, D we can define two planes. Plane 1 will have atom A-B-C and plane 2 will have atom B-C-D atoms. The angle between these two planes is dihedral angle.

Using cartesian coordinates of four atoms we can calculate 3 vectors v1, v2 and v3 as shown in figure 1.
Eg.-   v1 = ( x2-x1 )  , ( y2-y1 )  , ( z2-z1 ) likewise v2 and v3.

Get normal vectors to both of planes, first normal vector will be cross product of v1 and v2 
(v1 X v2), second normal vector will be cross product of vector v2 and v3 (v2 X v3). Name these normal vectors v4 and v5.

The angle between these two vectors v4 and v5 will be dot product of these vectors. This is dihedral angle.

To get rotation use vector v2. Vector produced by cross product of v4 and v5 will be either parallel or anti-parallel to v2 that can be used to determine rotation clockwise or anticlockwise.



Finding out Dihedral angle using RasMol - 

To find out dihedral angle using RasMol first choose CPK color by selecting "Colours" -> "CPK" and label atoms by selecting "Settings" -> "Pick Label", then clicking on individual atom or by selecting "Options" -> "Labels".
then select "Settings" -> "Pick Torsion" and choose four atoms for which we have to find out dihedral angle,
To find out phi of a residue "n" select atom CO of residue n-1 then N of n then Cα of n then CO of n
To find out psi of a residue "n" select N of n then Cα of n then CO of n then N of residue n+1.


Find out Dihedral Angle using RasMol
Find out Dihedral Angle using RasMol

Find out Dihedral Angle using RasMol
Find out Dihedral Angle using RasMol

N, CA, CO atoms in PDB Atom record will be represented as "N", "CA", "C" (column number 3)

PDB Atom Record